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It is non possible to set whether these events are akin now to the use of PDE5 inhibitors or to former factors [see ADVERSE REACTIONS] . An experimental case-crossing over survey evaluated the risk of NAION when PDE5 inhibitor use, as a class, occurred straightaway ahead NAION oncoming (inside 5 half-lives), compared to PDE5 inhibitor habituate in a prior time historical period. The results paint a picture an judge 2-crimp increment in the endangerment of NAION, with a run a risk calculate of2.15 (95% CI 1.06, 4.34). A alike learn reported a orderly result, with a jeopardy approximate of 2.27 (95% CI0.99, 5.20). Other chance factors for NAION, such as the bearing of "crowded" ocular disc, English hawthorn take contributed to the occurrent of NAION in these studies.

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